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Otsuka group was founded in Tokushima, Japan in 1921 and has spent more than a century building a reputation in Japanese Science and Skincare Research.
Sakuraé is a Japanese skincare brand developed by Otsuka Pharmaceutical around a simple belief: healthy-looking skin is beautiful skin. Rather than focusing only on correcting visible concerns, Sakuraé is designed to support the healthy looking skin natural renewal process and help reveal visibly more even, radiant skin over time.
AMP, Adenosine Monophosphate (Disodium Adenosine Monophosphate OT) is Otsuka's proprietary active ingredient, at the heart of Sakurae Double Action Serum. Developed over 20 years of research, it is designed to support healthy looking skin natural renewal for a more even radiant look over time.
LVC, Long-lasting Vitamin C (Ascorbic Acid 2-Glucoside) is a stable form of Vitamin C and the second half of Sakuraé Double Action Serum. Unlike pure Vitamin C which can break down quickly when expose to light or air, LVC is designed to hold its potency, so it stays effective through daily use. It works alongside AMP to help support a more even radiant looking complexion.
AMP and LVC address skin tone from 2 directions. AMP supports healthy looking skin natural renewal, helping it clear what it is naturally holding. LVC helps limit the look of UV induced spots as they form. Most serums focus on one or the other, Sakuraé double action serum pairs both so results build instead of stall.
Each Trial Kit includes 28 single-use sachets, for 14 full days of the complete Double Action Serum. (Use one sachet in the morning and one sachet in the evening). Each kit also includes the Sakuraé Booklet, introducing the brand’s philosophy of healthy-looking skin, the science behind the formula, and what to expect throughout your first weeks of use.
Simple. We'd rather you feel the difference yourself than take our word for it. So the Double Action Serum in your 14-day Trial Kit is free. You cover shipping, nothing more.
When your 14 days are up, your Sakuraé subscription begins automatically: a full-size Double Action Serum, delivered every month at $85/month. Prefer to stop there? Cancel anytime before day 14 at no charge — online through your account, or with our customer care team. Either way, we'll remind you before your trial ends.
Yes. You can cancel anytime before the end of your trial kit, with no additional charge. To cancel: manage your subscription in your account, contact us at hello@sakurae.us or call our dedicated customer service team - 1-833-OTSUKA8 (1-833-687-8528)
If you don't cancel, your Sakuraé subscription begins: a full-size Double Action Serum ships monthly at $85, delivered on your schedule. You can pause, change, or cancel anytime.
Skin renews on its own gradual cycle, so results build over time. But many people notice their skin looking more radiant within the first two weeks, the length of the trial. In a clinical study*, skin looked visibly more even and radiant in four weeks of twice-daily use.Improvement continues the longer you use it. Individual results vary.
*Clinical study, 54 women ages 31–59, vs. the same formula without AMP technology.
Skin renews gradually, so results build with consistent use. In a clinical study, skin looked visibly more even and radiant in four weeks of twice-daily use* with continued improvement the longer you use it. That's why Sakuraé is designed as an ongoing routine rather than a one-time fix.
*Clinical study, 54 women ages 31–59, vs. the same formula without AMP technology.
Apply 3 drops to the entire face morning and night, immediately after cleansing and before other serums or moisturizers.
We recommend applying it across the entire face rather than spot-treating. Using it evenly helps support healthy-looking skin renewal and a more even-looking tone across all of your skin, not just in isolated areas.
Yes. Apply Sakuraé first, right after cleansing, then layer your other serums, treatments, and moisturizers on top.
Sakuraé is compatible with most skincare, including retinol. Apply Sakuraé first, after cleansing, then layer other actives. If you use prescription treatments, we recommend checking with your dermatologist before adding any new product to your routine.
Use Sakuraé twice daily, morning and night. Apply it first, right after cleansing and before heavier serums, treatments, or moisturizer. In the morning, finish with a broad-spectrum SPF 30+.
Yes. After applying to your face, you can extend Sakuraé down the neck and chest, and anywhere you'd like to support a more even-looking tone. Spread gently and press into the skin, working outward.
Yes. Sakuraé is designed for twice-daily use, morning and night. In the morning, follow with a broad-spectrum SPF 30+ sunscreen; daily sun protection is recommended with any Vitamin C product and helps protect your results.
Sakuraé does not contain SPF and isn't a replacement for sunscreen. Because it contains Vitamin C, we recommend following it with a broad-spectrum SPF 30+ every morning, daily sun protection also helps protect your results.
You can find the complete ingredient list on the product page and on the packaging of our products. Sakuraé's two key actives are AMP (Adenosine Monophosphate or Disodium Adenosine Phosphate) and LVC (Long-lasting Vitamin C or Ascorbyl Glucoside), a stable form of Vitamin C.
Here is the full list: WATER, PENTAERYTHRITYL TETRAETHYLHEXANOATE, GLYCERIN, SQUALANE, DISODIUM ADENOSINE PHOSPHATE, PENTYLENE GLYCOL, ASCORBYL GLUCOSIDE, TROMETHAMINE, BIOSACCHARIDE GUM-1, DIGLYCERIN, METHYL GLUCETH-10, PHYTOSTERYL ISOSTEARATE, PHYTOSTERYL MACADAMIATE, CAPRYLIC/CAPRIC/MYRISTIC/STEARIC TRIGLYCERIDE, BIS-ETHOXYDIGLYCOL CYCLOHEXANE 1,4-DICARBOXYLATE, POLYGLYCERIN-3, SODIUM DILAURAMIDOGLUTAMIDE LYSINE, ACRYLATES/C10-30 ALKYL ACRYLATE CROSSPOLYMER, 1,2-HEXANEDIOL, PHENOXYETHANOL, PENTASODIUM TRIPHOSPHATE, FRAGRANCE.
No, Sakuraé is formulated without alcohol.
Sakuraé contains a light fragrance.
Yes.
The airless pump prevents oxidation, protecting the formula and letting you use every last drop. The translucent, blush-toned bottle echoes the result Sakuraé is designed for: skin that looks luminous from within.
Sakuraé is made in Japan.
A full size bottle of 33ml should last 1 month with twice daily use.
Sakuraé will be refillable soon (2027). You will keep the bottle, and simply replace the inner refill when it runs out. It's better for the environment and means you're not paying for new packaging every time.
Yes. Sakuraé is formulated for all skin types, including oily, dry, combination, and mature skin. Its lightweight texture absorbs quickly and layers easily under other products. If your skin is sensitive, see "Is it suitable for sensitive skin?" below for how to introduce it gradually.
We recommend a patch test before full-face use. If you've reacted to Vitamin C before, start with one application daily for the first week, then build up to morning and night
Yes. Sakuraé is designed to support a more even, radiant-looking tone on all skin tones. It works with your skin's natural renewal rather than lightening or altering your natural complexion.
Cleanse the inner arm, apply a small amount, and check immediately and again after 24 hours for redness or bumps. If you see no reaction, you can proceed to full-face use.
We recommend consulting your healthcare provider before use.
Yes, Sakuraé is compatible with most skincare. Apply it first, right after cleansing, then layer your other actives on top.
A little tingling on first use can be normal, but if you notice redness or irritation, stop use. If irritation persists beyond a few hours, consult a dermatologist.
Apply it to clear areas of skin and avoid active breakouts. If your skin is significantly broken out, we'd recommend checking with a dermatologist first.
Unopened, 3 years at room temperature. Once opened, use until empty, typically 1–2 months with twice-daily use.
Rinse immediately with water or a saline solution. If irritation persists, see an eye care professional.
Your free trial converts into a subscription unless you cancel. After your 14-day trial, you'll receive a full-size Double Action Serum for $85, shipped every 30 days. You can pause, change frequency, or cancel anytime, see "How do I cancel" below.
Your first full-size order is charged on day 15, just after your 14-day trial ends. You'll then be charged every 30 days on that same date. We'll email you before your trial ends, so you can cancel first if Sakuraé isn't right for you.
You can cancel anytime, including before day 15 to avoid your first full-size charge. You can cancel through your account, by emailing hello@sakurae.us or by contacting our customer service team at 1-833-OTSUKA8 (1-833-687-8528). Cancellation takes effect immediately before your next billing date.
Yes. You can cancel through your account, by emailing hello@sakurae.us or by contacting our customer service team at 1-833-OTSUKA8 (1-833-687-8528).
Yes. You can change how often your serum ships anytime through your account, by emailing hello@sakurae.us or by contacting our customer service team at 1-833-OTSUKA8 (1-833-687-8528).
Credit card, debit card, Apple Pay, Google Pay, and PayPal.
Orders ship within 2 business days and arrive within 3–5 business days of dispatch. Your free trial kit ships on the same timeline.
We currently ship within the Continental United States. We don’t ship internationally.
The 14-day trial kit is free when you subscribe to a full size bottle, you pay only shipping. Shipping cost may vary depending on your delivery address. Orders over $40 ship for free.
Contact us at 1-833-OTSUKA8 (1-833-687-8528).with your tracking number. We'll reship or refund within 5 to 10 days of verification.
